diff --git a/test/e2e/common_test.go b/test/e2e/common_test.go
index 65b957751a..772734b898 100644
--- a/test/e2e/common_test.go
+++ b/test/e2e/common_test.go
@@ -434,7 +434,8 @@ func (p *PodmanTestIntegration) RunTopContainer(name string) *PodmanSessionInteg
 // RunTopContainerWithArgs runs a simple container in the background that
 // runs top.  If the name passed != "", it will have a name, command args can also be passed in
 func (p *PodmanTestIntegration) RunTopContainerWithArgs(name string, args []string) *PodmanSessionIntegration {
-	var podmanArgs = []string{"run"}
+	// In proxy environment, some tests need to the --http-proxy=false option (#16684)
+	var podmanArgs = []string{"run", "--http-proxy=false"}
 	if name != "" {
 		podmanArgs = append(podmanArgs, "--name", name)
 	}
@@ -476,6 +477,17 @@ func (p *PodmanTestIntegration) RunNginxWithHealthCheck(name string) (*PodmanSes
 	return session, session.OutputToString()
 }
 
+// RunContainerWithNetworkTest runs the fedoraMinimal curl with the specified network mode.
+func (p *PodmanTestIntegration) RunContainerWithNetworkTest(mode string) *PodmanSessionIntegration {
+	var podmanArgs = []string{"run"}
+	if mode != "" {
+		podmanArgs = append(podmanArgs, "--network", mode)
+	}
+	podmanArgs = append(podmanArgs, fedoraMinimal, "curl", "-k", "-o", "/dev/null", "http://www.podman.io:80")
+	session := p.Podman(podmanArgs)
+	return session
+}
+
 func (p *PodmanTestIntegration) RunLsContainerInPod(name, pod string) (*PodmanSessionIntegration, int, string) {
 	var podmanArgs = []string{"run", "--pod", pod}
 	if name != "" {
diff --git a/test/e2e/generate_kube_test.go b/test/e2e/generate_kube_test.go
index 3c7b19f6a1..73db99cd4c 100644
--- a/test/e2e/generate_kube_test.go
+++ b/test/e2e/generate_kube_test.go
@@ -1251,7 +1251,8 @@ USER test1`
 
 		ctrName := "gen-kube-env-ctr"
 		podName := "gen-kube-env"
-		session1 := podmanTest.Podman([]string{"run", "-d", "--pod", "new:" + podName, "--name", ctrName,
+		// In proxy environment, this test needs to the --http-proxy=false option (#16684)
+		session1 := podmanTest.Podman([]string{"run", "-d", "--http-proxy=false", "--pod", "new:" + podName, "--name", ctrName,
 			"-e", "FOO=bar",
 			"-e", "HELLO=WORLD",
 			"alpine", "top"})
diff --git a/test/e2e/run_networking_test.go b/test/e2e/run_networking_test.go
index 4ad6772a4e..3afb640d62 100644
--- a/test/e2e/run_networking_test.go
+++ b/test/e2e/run_networking_test.go
@@ -42,38 +42,37 @@ var _ = Describe("Podman run networking", func() {
 	})
 
 	It("podman run network connection with default bridge", func() {
-		session := podmanTest.Podman([]string{"run", "-dt", ALPINE, "wget", "www.podman.io"})
-		session.Wait(90)
+		session := podmanTest.RunContainerWithNetworkTest("")
+		session.WaitWithDefaultTimeout()
 		Expect(session).Should(Exit(0))
 	})
 
 	It("podman run network connection with host", func() {
-		session := podmanTest.Podman([]string{"run", "-dt", "--network", "host", ALPINE, "wget", "www.podman.io"})
-		session.Wait(90)
+		session := podmanTest.RunContainerWithNetworkTest("host")
+		session.WaitWithDefaultTimeout()
 		Expect(session).Should(Exit(0))
 	})
 
 	It("podman run network connection with default", func() {
-		session := podmanTest.Podman([]string{"run", "--network", "default", ALPINE, "wget", "www.podman.io"})
+		session := podmanTest.RunContainerWithNetworkTest("default")
 		session.WaitWithDefaultTimeout()
 		Expect(session).Should(Exit(0))
 	})
 
 	It("podman run network connection with none", func() {
-		session := podmanTest.Podman([]string{"run", "--network", "none", ALPINE, "wget", "www.podman.io"})
+		session := podmanTest.RunContainerWithNetworkTest("none")
 		session.WaitWithDefaultTimeout()
-		Expect(session).Should(Exit(1))
-		Expect(session.ErrorToString()).To(ContainSubstring("wget: bad address 'www.podman.io'"))
+		if _, found := os.LookupEnv("http_proxy"); found {
+			Expect(session).Should(Exit(5))
+			Expect(session.ErrorToString()).To(ContainSubstring("Could not resolve proxy:"))
+		} else {
+			Expect(session).Should(Exit(6))
+			Expect(session.ErrorToString()).To(ContainSubstring("Could not resolve host: www.podman.io"))
+		}
 	})
 
 	It("podman run network connection with private", func() {
-		session := podmanTest.Podman([]string{"run", "--network", "private", ALPINE, "wget", "www.podman.io"})
-		session.WaitWithDefaultTimeout()
-		Expect(session).Should(Exit(0))
-	})
-
-	It("podman run network connection with loopback", func() {
-		session := podmanTest.Podman([]string{"run", "--network", "host", ALPINE, "wget", "www.podman.io"})
+		session := podmanTest.RunContainerWithNetworkTest("private")
 		session.WaitWithDefaultTimeout()
 		Expect(session).Should(Exit(0))
 	})
diff --git a/test/e2e/systemd_activate_test.go b/test/e2e/systemd_activate_test.go
index 240139b980..b33a7887f1 100644
--- a/test/e2e/systemd_activate_test.go
+++ b/test/e2e/systemd_activate_test.go
@@ -65,6 +65,8 @@ var _ = Describe("Systemd activate", func() {
 		addr := net.JoinHostPort(host, strconv.Itoa(port))
 
 		activateSession := testUtils.StartSystemExec(activate, []string{
+			"-E", "http_proxy", "-E", "https_proxy", "-E", "no_proxy",
+			"-E", "HTTP_PROXY", "-E", "HTTPS_PROXY", "-E", "NO_PROXY",
 			"--listen", addr,
 			podmanTest.PodmanBinary,
 			"--root=" + filepath.Join(tempDir, "server_root"),