diff --git a/netty/src/main/java/io/grpc/netty/NettyClientTransport.java b/netty/src/main/java/io/grpc/netty/NettyClientTransport.java
index f6a87d3a8e..203a28cf44 100644
--- a/netty/src/main/java/io/grpc/netty/NettyClientTransport.java
+++ b/netty/src/main/java/io/grpc/netty/NettyClientTransport.java
@@ -59,6 +59,7 @@ import java.net.SocketAddress;
 import java.nio.channels.ClosedChannelException;
 import java.util.Map;
 import java.util.concurrent.Executor;
+import java.util.concurrent.TimeUnit;
 import javax.annotation.Nullable;
 
 /**
@@ -220,6 +221,13 @@ class NettyClientTransport implements ConnectionClientTransport {
     b.channelFactory(channelFactory);
     // For non-socket based channel, the option will be ignored.
     b.option(SO_KEEPALIVE, true);
+    // For non-epoll based channel, the option will be ignored.
+    if (keepAliveTimeNanos != KEEPALIVE_TIME_NANOS_DISABLED) {
+      ChannelOption<Integer> tcpUserTimeout = Utils.maybeGetTcpUserTimeoutOption();
+      if (tcpUserTimeout != null) {
+        b.option(tcpUserTimeout, (int) TimeUnit.NANOSECONDS.toMillis(keepAliveTimeNanos));
+      }
+    }
     for (Map.Entry<ChannelOption<?>, ?> entry : channelOptions.entrySet()) {
       // Every entry in the map is obtained from
       // NettyChannelBuilder#withOption(ChannelOption<T> option, T value)
diff --git a/netty/src/main/java/io/grpc/netty/Utils.java b/netty/src/main/java/io/grpc/netty/Utils.java
index db52284f87..6675779479 100644
--- a/netty/src/main/java/io/grpc/netty/Utils.java
+++ b/netty/src/main/java/io/grpc/netty/Utils.java
@@ -54,6 +54,7 @@ import java.util.concurrent.TimeUnit;
 import java.util.logging.Level;
 import java.util.logging.Logger;
 import javax.annotation.CheckReturnValue;
+import javax.annotation.Nullable;
 
 /**
  * Common utility methods.
@@ -71,7 +72,6 @@ class Utils {
   public static final AsciiString TE_HEADER = AsciiString.of(GrpcUtil.TE_HEADER.name());
   public static final AsciiString TE_TRAILERS = AsciiString.of(GrpcUtil.TE_TRAILERS);
   public static final AsciiString USER_AGENT = AsciiString.of(GrpcUtil.USER_AGENT_KEY.name());
-
   public static final Resource<EventLoopGroup> NIO_BOSS_EVENT_LOOP_GROUP
       = new DefaultEventLoopGroupResource(1, "grpc-nio-boss-ELG", NioEventLoopGroup.class);
   public static final Resource<EventLoopGroup> NIO_WORKER_EVENT_LOOP_GROUP
@@ -281,6 +281,31 @@ class Utils {
     }
   }
 
+  /**
+   * Returns TCP_USER_TIMEOUT channel option for Epoll channel if Epoll is available, otherwise
+   * null.
+   */
+  @Nullable
+  static ChannelOption<Integer> maybeGetTcpUserTimeoutOption() {
+    return getEpollChannelOption("TCP_USER_TIMEOUT");
+  }
+
+  @Nullable
+  @SuppressWarnings("unchecked")
+  private static <T> ChannelOption<T> getEpollChannelOption(String optionName) {
+    if (isEpollAvailable()) {
+      try {
+        return
+            (ChannelOption<T>) Class.forName("io.netty.channel.epoll.EpollChannelOption")
+                .getField(optionName)
+                .get(null);
+      } catch (Exception e) {
+        throw new RuntimeException("ChannelOption(" + optionName + ") is not available", e);
+      }
+    }
+    return null;
+  }
+
   private static final class DefaultEventLoopGroupResource implements Resource<EventLoopGroup> {
     private final String name;
     private final int numEventLoops;
diff --git a/netty/src/test/java/io/grpc/netty/NettyClientTransportTest.java b/netty/src/test/java/io/grpc/netty/NettyClientTransportTest.java
index f0a557ab9f..6224a5d67e 100644
--- a/netty/src/test/java/io/grpc/netty/NettyClientTransportTest.java
+++ b/netty/src/test/java/io/grpc/netty/NettyClientTransportTest.java
@@ -18,6 +18,7 @@ package io.grpc.netty;
 
 import static com.google.common.base.Charsets.UTF_8;
 import static com.google.common.truth.Truth.assertThat;
+import static com.google.common.truth.TruthJUnit.assume;
 import static io.grpc.internal.GrpcUtil.DEFAULT_MAX_MESSAGE_SIZE;
 import static io.grpc.internal.GrpcUtil.DEFAULT_SERVER_KEEPALIVE_TIMEOUT_NANOS;
 import static io.grpc.internal.GrpcUtil.DEFAULT_SERVER_KEEPALIVE_TIME_NANOS;
@@ -69,6 +70,7 @@ import io.netty.channel.ChannelConfig;
 import io.netty.channel.ChannelFactory;
 import io.netty.channel.ChannelHandler;
 import io.netty.channel.ChannelOption;
+import io.netty.channel.EventLoopGroup;
 import io.netty.channel.ReflectiveChannelFactory;
 import io.netty.channel.local.LocalChannel;
 import io.netty.channel.nio.NioEventLoopGroup;
@@ -480,7 +482,8 @@ public class NettyClientTransportTest {
     startServer();
     NettyClientTransport transport = newTransport(newNegotiator(),
         DEFAULT_MAX_MESSAGE_SIZE, GrpcUtil.DEFAULT_MAX_HEADER_LIST_SIZE, "testUserAgent", true,
-        new ReflectiveChannelFactory<>(NioSocketChannel.class));
+        TimeUnit.SECONDS.toNanos(10L), new ReflectiveChannelFactory<>(NioSocketChannel.class),
+        group);
 
     callMeMaybe(transport.start(clientTransportListener));
 
@@ -493,7 +496,7 @@ public class NettyClientTransportTest {
     startServer();
     NettyClientTransport transport = newTransport(newNegotiator(),
         DEFAULT_MAX_MESSAGE_SIZE, GrpcUtil.DEFAULT_MAX_HEADER_LIST_SIZE, "testUserAgent", true,
-        new ReflectiveChannelFactory<>(LocalChannel.class));
+        TimeUnit.SECONDS.toNanos(10L), new ReflectiveChannelFactory<>(LocalChannel.class), group);
 
     callMeMaybe(transport.start(clientTransportListener));
 
@@ -609,6 +612,55 @@ public class NettyClientTransportTest {
     assertNull(transport.keepAliveManager());
   }
 
+  @Test
+  public void keepAliveEnabled_shouldSetTcpUserTimeout() throws Exception {
+    assume().that(Utils.isEpollAvailable()).isTrue();
+
+    startServer();
+    EventLoopGroup epollGroup = Utils.DEFAULT_WORKER_EVENT_LOOP_GROUP.create();
+    int keepAliveTimeMillis = 1234567;
+    try {
+      NettyClientTransport transport = newTransport(newNegotiator(), DEFAULT_MAX_MESSAGE_SIZE,
+          GrpcUtil.DEFAULT_MAX_HEADER_LIST_SIZE, null /* user agent */, true /* keep alive */,
+          TimeUnit.MILLISECONDS.toNanos(keepAliveTimeMillis),
+          new ReflectiveChannelFactory<>(Utils.DEFAULT_CLIENT_CHANNEL_TYPE), epollGroup);
+
+      callMeMaybe(transport.start(clientTransportListener));
+
+      ChannelOption<Integer> tcpUserTimeoutOption = Utils.maybeGetTcpUserTimeoutOption();
+      assertThat(tcpUserTimeoutOption).isNotNull();
+      // on some linux based system, the integer value may have error (usually +-1)
+      assertThat((double) transport.channel().config().getOption(tcpUserTimeoutOption))
+          .isWithin(5.0).of((double) keepAliveTimeMillis);
+    } finally {
+      epollGroup.shutdownGracefully();
+    }
+  }
+
+  @Test
+  public void keepAliveDisabled_shouldNotSetTcpUserTimeout() throws Exception {
+    assume().that(Utils.isEpollAvailable()).isTrue();
+
+    startServer();
+    EventLoopGroup epollGroup = Utils.DEFAULT_WORKER_EVENT_LOOP_GROUP.create();
+    int keepAliveTimeMillis = 12345670;
+    try {
+      NettyClientTransport transport = newTransport(newNegotiator(), DEFAULT_MAX_MESSAGE_SIZE,
+          GrpcUtil.DEFAULT_MAX_HEADER_LIST_SIZE, null /* user agent */, false /* keep alive */,
+          TimeUnit.MILLISECONDS.toNanos(keepAliveTimeMillis),
+          new ReflectiveChannelFactory<>(Utils.DEFAULT_CLIENT_CHANNEL_TYPE), epollGroup);
+
+      callMeMaybe(transport.start(clientTransportListener));
+
+      ChannelOption<Integer> tcpUserTimeoutOption = Utils.maybeGetTcpUserTimeoutOption();
+      assertThat(tcpUserTimeoutOption).isNotNull();
+      // default TCP_USER_TIMEOUT=0 (use the system default)
+      assertThat(transport.channel().config().getOption(tcpUserTimeoutOption)).isEqualTo(0);
+    } finally {
+      epollGroup.shutdownGracefully();
+    }
+  }
+
   private Throwable getRootCause(Throwable t) {
     if (t.getCause() == null) {
       return t;
@@ -631,16 +683,16 @@ public class NettyClientTransportTest {
   private NettyClientTransport newTransport(ProtocolNegotiator negotiator, int maxMsgSize,
       int maxHeaderListSize, String userAgent, boolean enableKeepAlive) {
     return newTransport(negotiator, maxMsgSize, maxHeaderListSize, userAgent, enableKeepAlive,
-        new ReflectiveChannelFactory<>(NioSocketChannel.class));
+        TimeUnit.SECONDS.toNanos(10L), new ReflectiveChannelFactory<>(NioSocketChannel.class),
+        group);
   }
 
   private NettyClientTransport newTransport(ProtocolNegotiator negotiator, int maxMsgSize,
-      int maxHeaderListSize, String userAgent, boolean enableKeepAlive,
-      ChannelFactory<? extends Channel> channelFactory) {
-    long keepAliveTimeNano = KEEPALIVE_TIME_NANOS_DISABLED;
+      int maxHeaderListSize, String userAgent, boolean enableKeepAlive, long keepAliveTimeNano,
+      ChannelFactory<? extends Channel> channelFactory, EventLoopGroup group) {
     long keepAliveTimeoutNano = TimeUnit.SECONDS.toNanos(1L);
-    if (enableKeepAlive) {
-      keepAliveTimeNano = TimeUnit.SECONDS.toNanos(10L);
+    if (!enableKeepAlive) {
+      keepAliveTimeNano = KEEPALIVE_TIME_NANOS_DISABLED;
     }
     NettyClientTransport transport = new NettyClientTransport(
         address, channelFactory, new HashMap<ChannelOption<?>, Object>(), group,
diff --git a/netty/src/test/java/io/grpc/netty/UtilsTest.java b/netty/src/test/java/io/grpc/netty/UtilsTest.java
index d9dc4dd2a0..bb66d29c2a 100644
--- a/netty/src/test/java/io/grpc/netty/UtilsTest.java
+++ b/netty/src/test/java/io/grpc/netty/UtilsTest.java
@@ -212,4 +212,11 @@ public class UtilsTest {
     assertThat(clientChannelType.getName())
         .isEqualTo("io.netty.channel.epoll.EpollServerSocketChannel");
   }
+
+  @Test
+  public void maybeGetTcpUserTimeoutOption() {
+    assume().that(Utils.isEpollAvailable()).isTrue();
+
+    assertThat(Utils.maybeGetTcpUserTimeoutOption()).isNotNull();
+  }
 }