diff --git a/javascript/net/grpc/web/abstractclientbase.js b/javascript/net/grpc/web/abstractclientbase.js
index 21da4ac..63157cf 100644
--- a/javascript/net/grpc/web/abstractclientbase.js
+++ b/javascript/net/grpc/web/abstractclientbase.js
@@ -32,6 +32,20 @@ const MethodDescriptor = goog.require('grpc.web.MethodDescriptor');
 const RpcError = goog.require('grpc.web.RpcError');
 
 
+/**
+ * @constructor
+ * @struct
+ * @final
+ */
+const PromiseCallOptions = function() {};
+
+/**
+ * An AbortSignal to abort the call.
+ * @type {AbortSignal|undefined}
+ */
+PromiseCallOptions.prototype.signal;
+
+
 /**
  * This interface represents a grpc-web client
  * @interface
@@ -62,10 +76,11 @@ const AbstractClientBase = class {
    * @param {!Object<string, string>} metadata User defined call metadata
    * @param {!MethodDescriptor<REQUEST, RESPONSE>}
    *   methodDescriptor Information of this RPC method
+   * @param options Options for the call
    * @return {!IThenable<RESPONSE>}
    *   A promise that resolves to the response message
    */
-  thenableCall(method, requestMessage, metadata, methodDescriptor) {}
+  thenableCall(method, requestMessage, metadata, methodDescriptor, options) {}
 
   /**
    * @abstract
@@ -78,21 +93,19 @@ const AbstractClientBase = class {
    * @return {!ClientReadableStream<RESPONSE>} The Client Readable Stream
    */
   serverStreaming(method, requestMessage, metadata, methodDescriptor) {}
-
-  /**
-   * Get the hostname of the current request.
-   * @static
-   * @template REQUEST, RESPONSE
-   * @param {string} method
-   * @param {!MethodDescriptor<REQUEST,RESPONSE>} methodDescriptor
-   * @return {string}
-   */
-  static getHostname(method, methodDescriptor) {
-    // method = hostname + methodDescriptor.name(relative path of this method)
-    return method.substr(0, method.length - methodDescriptor.name.length);
-  }
 };
 
+/**
+ * Get the hostname of the current request.
+ * @template REQUEST, RESPONSE
+ * @param {string} method
+ * @param {!MethodDescriptor<REQUEST,RESPONSE>} methodDescriptor
+ * @return {string}
+ */
+function getHostname(method, methodDescriptor) {
+  // method = hostname + methodDescriptor.name(relative path of this method)
+  return method.substr(0, method.length - methodDescriptor.name.length);
+}
 
 
-exports = AbstractClientBase;
+exports = {AbstractClientBase, PromiseCallOptions, getHostname};
diff --git a/javascript/net/grpc/web/grpcwebclientbase.js b/javascript/net/grpc/web/grpcwebclientbase.js
index 999e4cb..93f2eff 100644
--- a/javascript/net/grpc/web/grpcwebclientbase.js
+++ b/javascript/net/grpc/web/grpcwebclientbase.js
@@ -28,7 +28,6 @@ goog.module('grpc.web.GrpcWebClientBase');
 goog.module.declareLegacyNamespace();
 
 
-const AbstractClientBase = goog.require('grpc.web.AbstractClientBase');
 const ClientOptions = goog.requireType('grpc.web.ClientOptions');
 const ClientReadableStream = goog.require('grpc.web.ClientReadableStream');
 const ClientUnaryCallImpl = goog.require('grpc.web.ClientUnaryCallImpl');
@@ -40,6 +39,7 @@ const RpcError = goog.require('grpc.web.RpcError');
 const StatusCode = goog.require('grpc.web.StatusCode');
 const XhrIo = goog.require('goog.net.XhrIo');
 const googCrypt = goog.require('goog.crypt.base64');
+const {AbstractClientBase, PromiseCallOptions, getHostname} = goog.require('grpc.web.AbstractClientBase');
 const {Status} = goog.require('grpc.web.Status');
 const {StreamInterceptor, UnaryInterceptor} = goog.require('grpc.web.Interceptor');
 const {toObject} = goog.require('goog.collections.maps');
@@ -101,7 +101,7 @@ class GrpcWebClientBase {
    * @export
    */
   rpcCall(method, requestMessage, metadata, methodDescriptor, callback) {
-    const hostname = AbstractClientBase.getHostname(method, methodDescriptor);
+    const hostname = getHostname(method, methodDescriptor);
     const invoker = GrpcWebClientBase.runInterceptors_(
         (request) => this.startStream_(request, hostname),
         this.streamInterceptors_);
@@ -112,18 +112,35 @@ class GrpcWebClientBase {
   }
 
   /**
-   * @override
-   * @export
+   * @param {string} method The method to invoke
+   * @param {REQUEST} requestMessage The request proto
+   * @param {!Object<string, string>} metadata User defined call metadata
+   * @param {!MethodDescriptor<REQUEST, RESPONSE>} methodDescriptor
+   * @param {?PromiseCallOptions=} options Options for the call
+   * @return {!Promise<RESPONSE>}
+   * @template REQUEST, RESPONSE
    */
-  thenableCall(method, requestMessage, metadata, methodDescriptor) {
-    const hostname = AbstractClientBase.getHostname(method, methodDescriptor);
+  thenableCall(
+      method, requestMessage, metadata, methodDescriptor, options = {}) {
+    const hostname = getHostname(method, methodDescriptor);
+    const signal = options && options.signal;
     const initialInvoker = (request) => new Promise((resolve, reject) => {
+      // If the signal is already aborted, immediately reject the promise
+      // and don't issue the call.
+      if (signal && signal.aborted) {
+        const error = new RpcError(StatusCode.CANCELLED, 'Aborted');
+        error.cause = signal.reason;
+        reject(error);
+        return;
+      }
+
       const stream = this.startStream_(request, hostname);
       let unaryMetadata;
       let unaryStatus;
       let unaryMsg;
       GrpcWebClientBase.setCallback_(
-          stream, (error, response, status, metadata, unaryResponseReceived) => {
+          stream,
+          (error, response, status, metadata, unaryResponseReceived) => {
             if (error) {
               reject(error);
             } else if (unaryResponseReceived) {
@@ -136,7 +153,19 @@ class GrpcWebClientBase {
               resolve(request.getMethodDescriptor().createUnaryResponse(
                   unaryMsg, unaryMetadata, unaryStatus));
             }
-          }, true);
+          },
+          true);
+
+      // Wire up cancellation from the abort signal, if any.
+      if (signal) {
+        signal.addEventListener('abort', () => {
+          stream.cancel();
+
+          const error = new RpcError(StatusCode.CANCELLED, 'Aborted');
+          error.cause = /** @type {!AbortSignal} */ (signal).reason;
+          reject(error);
+        });
+      }
     });
     const invoker = GrpcWebClientBase.runInterceptors_(
         initialInvoker, this.unaryInterceptors_);
@@ -152,12 +181,13 @@ class GrpcWebClientBase {
    * @param {!Object<string, string>} metadata User defined call metadata
    * @param {!MethodDescriptor<REQUEST, RESPONSE>} methodDescriptor Information
    *     of this RPC method
+   * @param {?PromiseCallOptions=} options Options for the call
    * @return {!Promise<RESPONSE>}
    * @template REQUEST, RESPONSE
    */
-  unaryCall(method, requestMessage, metadata, methodDescriptor) {
-    return /** @type {!Promise<RESPONSE>}*/ (
-        this.thenableCall(method, requestMessage, metadata, methodDescriptor));
+  unaryCall(method, requestMessage, metadata, methodDescriptor, options = {}) {
+    return /** @type {!Promise<RESPONSE>}*/ (this.thenableCall(
+        method, requestMessage, metadata, methodDescriptor, options));
   }
 
   /**
@@ -165,7 +195,7 @@ class GrpcWebClientBase {
    * @export
    */
   serverStreaming(method, requestMessage, metadata, methodDescriptor) {
-    const hostname = AbstractClientBase.getHostname(method, methodDescriptor);
+    const hostname = getHostname(method, methodDescriptor);
     const invoker = GrpcWebClientBase.runInterceptors_(
         (request) => this.startStream_(request, hostname),
         this.streamInterceptors_);
@@ -279,7 +309,9 @@ class GrpcWebClientBase {
             message: 'Incomplete response',
           });
         } else if (useUnaryResponse) {
-          callback(null, responseReceived, null, null, /* unaryResponseReceived= */ true);
+          callback(
+            null, responseReceived, null, null,
+            /* unaryResponseReceived= */ true);
         } else {
           callback(null, responseReceived);
         }
@@ -368,12 +400,9 @@ class GrpcWebClientBase {
    *     (!Promise<RESPONSE>|!ClientReadableStream<RESPONSE>)}
    */
   static runInterceptors_(invoker, interceptors) {
-    let curInvoker = invoker;
-    interceptors.forEach((interceptor) => {
-      const lastInvoker = curInvoker;
-      curInvoker = (request) => interceptor.intercept(request, lastInvoker);
-    });
-    return curInvoker;
+    return interceptors.reduce((accumulatedInvoker, interceptor) => {
+      return (request) => interceptor.intercept(request, accumulatedInvoker);
+    }, invoker);
   }
 }
 
diff --git a/javascript/net/grpc/web/grpcwebclientbase_test.js b/javascript/net/grpc/web/grpcwebclientbase_test.js
index e361440..2a859bb 100644
--- a/javascript/net/grpc/web/grpcwebclientbase_test.js
+++ b/javascript/net/grpc/web/grpcwebclientbase_test.js
@@ -19,6 +19,7 @@ goog.module('grpc.web.GrpcWebClientBaseTest');
 goog.setTestOnly('grpc.web.GrpcWebClientBaseTest');
 
 const ClientReadableStream = goog.require('grpc.web.ClientReadableStream');
+const ErrorCode = goog.require('goog.net.ErrorCode');
 const GrpcWebClientBase = goog.require('grpc.web.GrpcWebClientBase');
 const MethodDescriptor = goog.require('grpc.web.MethodDescriptor');
 const ReadyState = goog.require('goog.net.XmlHttp.ReadyState');
@@ -146,6 +147,58 @@ testSuite({
     assertElementsEquals(DEFAULT_UNARY_HEADER_VALUES, Object.values(headers));
   },
 
+
+  async testCancelledThenableCall() {
+    const xhr = new XhrIo();
+    const client = new GrpcWebClientBase(/* options= */ {}, xhr);
+    const methodDescriptor = createMethodDescriptor((bytes) => {
+      assertElementsEquals(DEFAULT_RPC_RESPONSE_DATA, [].slice.call(bytes));
+      return 0;
+    });
+
+    const abortController = new AbortController();
+    const signal = abortController.signal;
+    const responsePromise = client.thenableCall(
+        'url', new MockRequest(), /* metadata= */ {}, methodDescriptor,
+        {signal});
+    abortController.abort();
+
+    const error = await assertRejects(responsePromise);
+    assertTrue(error instanceof RpcError);
+    assertEquals(StatusCode.CANCELLED, /** @type {!RpcError} */ (error).code);
+    assertEquals('Aborted', /** @type {!RpcError} */ (error).message);
+    // Default abort reason if none provided.
+    const cause = /** @type {!RpcError} */ (error).cause;
+    assertTrue(cause instanceof Error);
+    assertEquals('AbortError', /** @type {!Error} */ (cause).name);
+    assertEquals(ErrorCode.ABORT, xhr.getLastErrorCode());
+  },
+
+  async testCancelledThenableCallWithReason() {
+    const xhr = new XhrIo();
+    const client = new GrpcWebClientBase(/* options= */ {}, xhr);
+    const methodDescriptor = createMethodDescriptor((bytes) => {
+      assertElementsEquals(DEFAULT_RPC_RESPONSE_DATA, [].slice.call(bytes));
+      return 0;
+    });
+
+    const abortController = new AbortController();
+    const signal = abortController.signal;
+    const responsePromise = client.thenableCall(
+        'url', new MockRequest(), /* metadata= */ {}, methodDescriptor,
+        {signal});
+    abortController.abort('cancelling');
+
+    const error = await assertRejects(responsePromise);
+    assertTrue(error instanceof RpcError);
+    assertEquals(StatusCode.CANCELLED, /** @type {!RpcError} */ (error).code);
+    assertEquals('Aborted', /** @type {!RpcError} */ (error).message);
+    // Abort reason forwarded as cause.
+    const cause = /** @type {!RpcError} */ (error).cause;
+    assertEquals('cancelling', cause);
+    assertEquals(ErrorCode.ABORT, xhr.getLastErrorCode());
+  },
+
   async testDeadline() {
     const xhr = new XhrIo();
     const client = new GrpcWebClientBase(/* options= */ {}, xhr);
diff --git a/packages/grpc-web/docker/jsunit-test/Dockerfile b/packages/grpc-web/docker/jsunit-test/Dockerfile
index 29519f0..909da30 100644
--- a/packages/grpc-web/docker/jsunit-test/Dockerfile
+++ b/packages/grpc-web/docker/jsunit-test/Dockerfile
@@ -1,4 +1,4 @@
-FROM selenium/standalone-chrome:93.0.4577.63
+FROM selenium/standalone-chrome:112.0.5615.165
 
 # Matching the node version used in the node:20.0.0-bullseye image.
 ARG NODE_VERSION=20.0.0
diff --git a/packages/grpc-web/index.d.ts b/packages/grpc-web/index.d.ts
index 09fb671..fc01a07 100644
--- a/packages/grpc-web/index.d.ts
+++ b/packages/grpc-web/index.d.ts
@@ -7,7 +7,8 @@ declare module "grpc-web" {
       method: string,
       request: REQ,
       metadata: Metadata,
-      methodDescriptor: MethodDescriptor<REQ, RESP>
+      methodDescriptor: MethodDescriptor<REQ, RESP>,
+      options?: PromiseCallOptions
     ): Promise<RESP>;
 
     rpcCall<REQ, RESP> (
@@ -64,8 +65,10 @@ declare module "grpc-web" {
       Promise<UnaryResponse<REQ, RESP>>): Promise<UnaryResponse<REQ, RESP>>;
   }
 
-  export class CallOptions {
-    constructor(options: { [index: string]: any; });
+  /** Options for gRPC-Web calls returning a Promise. */
+  export interface PromiseCallOptions {
+    /** An AbortSignal to abort the call. */
+    readonly signal?: AbortSignal;
   }
 
   export class MethodDescriptor<REQ, RESP> {
@@ -82,7 +85,6 @@ declare module "grpc-web" {
     getRequestMessage(): REQ;
     getMethodDescriptor(): MethodDescriptor<REQ, RESP>;
     getMetadata(): Metadata;
-    getCallOptions(): CallOptions;
   }
 
   export class UnaryResponse<REQ, RESP> {
diff --git a/packages/grpc-web/scripts/run_jsunit_tests.sh b/packages/grpc-web/scripts/run_jsunit_tests.sh
index a3a5a05..95ed115 100755
--- a/packages/grpc-web/scripts/run_jsunit_tests.sh
+++ b/packages/grpc-web/scripts/run_jsunit_tests.sh
@@ -44,8 +44,8 @@ trap cleanup EXIT
 
 echo "Using Headless Chrome."
 # Updates Selenium Webdriver.
-echo "$PROTRACTOR_BIN_PATH/webdriver-manager update --versions.chrome=93.0.4577.63 --gecko=false"
-$PROTRACTOR_BIN_PATH/webdriver-manager update --versions.chrome=93.0.4577.63 --gecko=false
+echo "$PROTRACTOR_BIN_PATH/webdriver-manager update --versions.chrome=112.0.5615.165 --gecko=false"
+$PROTRACTOR_BIN_PATH/webdriver-manager update --versions.chrome=112.0.5615.165 --gecko=false
 
 # Run the tests using Protractor! (Protractor should run selenium automatically)
 $PROTRACTOR_BIN_PATH/protractor protractor.conf.js