diff --git a/go.mod b/go.mod
index c7ff4a0f3b..d32be1a28f 100644
--- a/go.mod
+++ b/go.mod
@@ -19,7 +19,7 @@ require (
 	github.com/golang/sync v0.0.0-20180314180146-1d60e4601c6f
 	github.com/pmezard/go-difflib v1.0.0
 	istio.io/client-go v1.13.0-beta.1.0.20220210233217-e58430254644 // indirect
-	istio.io/istio v0.0.0-20220211194614-5cb50f670dea
+	istio.io/istio v0.0.0-20220213095637-2a5e10406d79
 	istio.io/pkg v0.0.0-20220210214831-ae0a970bca81
 	k8s.io/apimachinery v0.23.3
 	k8s.io/client-go v0.23.3
diff --git a/go.sum b/go.sum
index 3ad97831de..085b2e533d 100644
--- a/go.sum
+++ b/go.sum
@@ -1998,18 +1998,17 @@ honnef.co/go/tools v0.0.0-20190523083050-ea95bdfd59fc/go.mod h1:rf3lG4BRIbNafJWh
 honnef.co/go/tools v0.0.1-2019.2.3/go.mod h1:a3bituU0lyd329TUQxRnasdCoJDkEUEAqEt0JzvZhAg=
 honnef.co/go/tools v0.0.1-2020.1.3/go.mod h1:X/FiERA/W4tHapMX5mGpAtMSVEeEUOyHaw9vFzvIQ3k=
 honnef.co/go/tools v0.0.1-2020.1.4/go.mod h1:X/FiERA/W4tHapMX5mGpAtMSVEeEUOyHaw9vFzvIQ3k=
-istio.io/api v0.0.0-20220210032859-49f540feee0b/go.mod h1:8ZZgyVgYrHhsFQarEgTfPnMGpdgTDZbxSjYhdwTUuAQ=
 istio.io/api v0.0.0-20220210232731-3f74d9d771e5/go.mod h1:8ZZgyVgYrHhsFQarEgTfPnMGpdgTDZbxSjYhdwTUuAQ=
-istio.io/api v0.0.0-20220211174259-6ad61f985616 h1:iCSu9HNHufM/dRtC73aYu7yO/JNYR4+lnA0q2YXwegs=
-istio.io/api v0.0.0-20220211174259-6ad61f985616/go.mod h1:8ZZgyVgYrHhsFQarEgTfPnMGpdgTDZbxSjYhdwTUuAQ=
-istio.io/client-go v1.12.0-alpha.5.0.20220210033504-c0149a01b11a/go.mod h1:Djf45uvAWdH9SeixxRDacNL/Yvg3H24gBa3P2tw6ltM=
+istio.io/api v0.0.0-20220211232855-07d3915aebf7 h1:ZdCT07xFC+EPQfztM02TPh4E/pqYHpTdycKlJvogEFI=
+istio.io/api v0.0.0-20220211232855-07d3915aebf7/go.mod h1:8ZZgyVgYrHhsFQarEgTfPnMGpdgTDZbxSjYhdwTUuAQ=
+istio.io/client-go v1.12.0-alpha.5.0.20220211234806-057940b7a8a2/go.mod h1:b1O3D2aTVt23QQv8LMoH1oyxdbmbtFFN6pwDCiZlpx8=
 istio.io/client-go v1.13.0-beta.1.0.20220210233217-e58430254644 h1:k/nh8fLaeim0Ah4eR7wVsby2OrxjQbPij43lFFQlnUc=
 istio.io/client-go v1.13.0-beta.1.0.20220210233217-e58430254644/go.mod h1:vclXCtVEwF/XEQTdmNuaiRlHIEneJpMnEVEhWFTbsrE=
 istio.io/gogo-genproto v0.0.0-20211208193508-5ab4acc9eb1e/go.mod h1:vJDAniIqryf/z///fgZqVPKJ7N2lBk7Gg8DCTB7oCfU=
 istio.io/gogo-genproto v0.0.0-20220203154911-542602f9bf4f h1:Qz/sQH9I2u8XfasvCNWmdMdjRendJc1gKi5NkLCpS5g=
 istio.io/gogo-genproto v0.0.0-20220203154911-542602f9bf4f/go.mod h1:vJDAniIqryf/z///fgZqVPKJ7N2lBk7Gg8DCTB7oCfU=
-istio.io/istio v0.0.0-20220211194614-5cb50f670dea h1:rRvc6Z9jpXspxUsd07C60QULW0bqnBUbgpNX/UY/e+A=
-istio.io/istio v0.0.0-20220211194614-5cb50f670dea/go.mod h1:AIoEj/8SbAChuhxXdARPhzzAD3K5wwjVsdR8ToU8GfE=
+istio.io/istio v0.0.0-20220213095637-2a5e10406d79 h1:DpOYlZ8VPGw3ggzYafZMSS5yWxZYl+DvHvNM0ZTUV3g=
+istio.io/istio v0.0.0-20220213095637-2a5e10406d79/go.mod h1:74toFf/fUtJl4zc/hqokAGuAZEa2jZwcRLYGcLEo6G0=
 istio.io/pkg v0.0.0-20220203154910-aa99fc270afc/go.mod h1:i95AmfHLCp5JThoiCGCyzZ6bOHJk5fD+BicBvGDr9Xg=
 istio.io/pkg v0.0.0-20220210214831-ae0a970bca81 h1:slvnEgbGWKfJc4kJXmoGvbChPrzLJcVh+XCiM+11D9s=
 istio.io/pkg v0.0.0-20220210214831-ae0a970bca81/go.mod h1:i95AmfHLCp5JThoiCGCyzZ6bOHJk5fD+BicBvGDr9Xg=
diff --git a/tests/setup/profile_default/doc_test.go b/tests/setup/profile_default/doc_test.go
index 14ce9a091e..9f64fe9ee0 100644
--- a/tests/setup/profile_default/doc_test.go
+++ b/tests/setup/profile_default/doc_test.go
@@ -22,10 +22,10 @@ import (
 )
 
 func TestMain(m *testing.M) {
+	// nolint: staticcheck
 	framework.
 		NewSuite(m).
 		Setup(istio.Setup(nil, nil)).
-		RequireSingleCluster().
 		Run()
 }
 
diff --git a/tests/setup/profile_demo/doc_test.go b/tests/setup/profile_demo/doc_test.go
index 3c5d537017..60b538606a 100644
--- a/tests/setup/profile_demo/doc_test.go
+++ b/tests/setup/profile_demo/doc_test.go
@@ -23,10 +23,10 @@ import (
 )
 
 func TestMain(m *testing.M) {
+	// nolint: staticcheck
 	framework.
 		NewSuite(m).
 		Setup(istio.Setup(nil, setupConfig)).
-		RequireSingleCluster().
 		Run()
 }
 
diff --git a/tests/setup/profile_none/doc_test.go b/tests/setup/profile_none/doc_test.go
index 8506ef353e..5cbdefe13f 100644
--- a/tests/setup/profile_none/doc_test.go
+++ b/tests/setup/profile_none/doc_test.go
@@ -22,7 +22,6 @@ import (
 
 func TestMain(m *testing.M) {
 	framework.NewSuite(m).
-		RequireSingleCluster().
 		Run()
 }