diff --git a/hack/run-e2e.sh b/hack/run-e2e.sh
new file mode 100755
index 000000000..4b198f74e
--- /dev/null
+++ b/hack/run-e2e.sh
@@ -0,0 +1,24 @@
+#!/usr/bin/env bash
+
+set -o errexit
+set -o nounset
+set -o pipefail
+
+# This script runs e2e test against on karmada control plane.
+# You should prepare your environment in advance and following environment may be you need to set or use default one.
+# - CONTROL_PLANE_KUBECONFIG: absolute path of control plane KUBECONFIG file.
+#
+# Usage: hack/run-e2e.sh
+# Example 1: hack/run-e2e.sh (run e2e with default config)
+# Example 2: export CONTROL_PLANE_KUBECONFIG=<KUBECONFIG PATH> hack/run-e2e.sh (run e2e with your KUBECONFIG)
+
+CONTROL_PLANE_KUBECONFIG=${CONTROL_PLANE_KUBECONFIG:-"${HOME}/.kube/karmada.config"}
+
+export KUBECONFIG=${CONTROL_PLANE_KUBECONFIG}
+
+# Install ginkgo
+GO111MODULE=on go install github.com/onsi/ginkgo
+
+# Run e2e
+export KUBECONFIG=${CONTROL_PLANE_KUBECONFIG}
+ginkgo -v -race -failFast ./test/e2e/
diff --git a/pkg/util/cluster.go b/pkg/util/cluster.go
new file mode 100644
index 000000000..6673e91ae
--- /dev/null
+++ b/pkg/util/cluster.go
@@ -0,0 +1,19 @@
+package util
+
+import (
+	"github.com/huawei-cloudnative/karmada/pkg/apis/membercluster/v1alpha1"
+	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
+)
+
+// IsMemberClusterReady tells whether the cluster in ready state via checking its conditions.
+func IsMemberClusterReady(cluster *v1alpha1.MemberCluster) bool {
+	for _, condition := range cluster.Status.Conditions {
+		// TODO(RainbowMango): Condition type should be defined in API, and after that update this hard code accordingly.
+		if condition.Type == "ClusterReady" {
+			if condition.Status == metav1.ConditionTrue {
+				return true
+			}
+		}
+	}
+	return false
+}
diff --git a/test/e2e/cluster_test.go b/test/e2e/cluster_test.go
new file mode 100644
index 000000000..563bd2b14
--- /dev/null
+++ b/test/e2e/cluster_test.go
@@ -0,0 +1,31 @@
+package e2e
+
+import (
+	"github.com/onsi/ginkgo"
+)
+
+var _ = ginkgo.Describe("[cluster-lifecycle] [cluster-join] cluster lifecycle functionality testing", func() {
+	ginkgo.BeforeEach(func() {
+		// TODO(RainbowMango): create a new member cluster which will be used by following tests.
+	})
+
+	ginkgo.AfterEach(func() {
+		// TODO(RainbowMango): remove member clusters that created for this test
+	})
+
+	ginkgo.Context("normal cluster join and unjoin functionality", func() {
+		ginkgo.It("new cluster could be joined to control plane", func() {
+			ginkgo.By("join new member cluster", func() {
+				// TODO(RainbowMango): add implementations here
+			})
+			ginkgo.By("check member cluster status", func() {
+				// TODO(RainbowMango): add implementations here
+			})
+			ginkgo.By("unjoin member cluster")
+		})
+	})
+
+	ginkgo.Context("abnormal cluster join and unjoin functionality", func() {
+		// TODO(RainbowMango): add implementations here
+	})
+})
diff --git a/test/e2e/suite_test.go b/test/e2e/suite_test.go
index d5219227e..02a23329a 100644
--- a/test/e2e/suite_test.go
+++ b/test/e2e/suite_test.go
@@ -1,11 +1,23 @@
 package e2e
 
 import (
+	"context"
+	"fmt"
+	"os"
 	"testing"
 	"time"
 
 	"github.com/onsi/ginkgo"
 	"github.com/onsi/gomega"
+
+	v1 "k8s.io/apimachinery/pkg/apis/meta/v1"
+	"k8s.io/client-go/kubernetes"
+	"k8s.io/client-go/rest"
+	"k8s.io/client-go/tools/clientcmd"
+	"k8s.io/klog/v2"
+
+	karmada "github.com/huawei-cloudnative/karmada/pkg/generated/clientset/versioned"
+	"github.com/huawei-cloudnative/karmada/pkg/util"
 )
 
 const (
@@ -13,6 +25,16 @@ const (
 	TestSuiteSetupTimeOut = 300 * time.Second
 	// TestSuiteTeardownTimeOut defines the time after which the suite tear down times out.
 	TestSuiteTeardownTimeOut = 300 * time.Second
+
+	// MinimumMemberCluster represents the minimum number of member clusters to run E2E test.
+	MinimumMemberCluster = 2
+)
+
+var (
+	kubeconfig    string
+	restConfig    *rest.Config
+	kubeClient    kubernetes.Interface
+	karmadaClient karmada.Interface
 )
 
 func TestE2E(t *testing.T) {
@@ -21,9 +43,48 @@ func TestE2E(t *testing.T) {
 }
 
 var _ = ginkgo.BeforeSuite(func() {
-	// suite set up, such as get karmada environment ready.
+	kubeconfig = os.Getenv("KUBECONFIG")
+	gomega.Expect(kubeconfig).ShouldNot(gomega.BeEmpty())
+
+	var err error
+	restConfig, err = clientcmd.BuildConfigFromFlags("", kubeconfig)
+	gomega.Expect(err).ShouldNot(gomega.HaveOccurred())
+
+	kubeClient, err = kubernetes.NewForConfig(restConfig)
+	gomega.Expect(err).ShouldNot(gomega.HaveOccurred())
+
+	karmadaClient, err = karmada.NewForConfig(restConfig)
+	gomega.Expect(err).ShouldNot(gomega.HaveOccurred())
+
+	meetRequirement, err := isMemberClusterMeetRequirements(karmadaClient)
+	gomega.Expect(err).ShouldNot(gomega.HaveOccurred())
+	gomega.Expect(meetRequirement).Should(gomega.BeTrue())
 }, TestSuiteSetupTimeOut.Seconds())
 
 var _ = ginkgo.AfterSuite(func() {
 	// suite tear down, such as cleanup karmada environment.
 }, TestSuiteTeardownTimeOut.Seconds())
+
+// isMemberClusterMeetRequirements checks if current environment meet the requirements of E2E.
+func isMemberClusterMeetRequirements(client karmada.Interface) (bool, error) {
+	// list all member cluster we have
+	clusters, err := client.MemberclusterV1alpha1().MemberClusters().List(context.TODO(), v1.ListOptions{})
+	if err != nil {
+		return false, err
+	}
+
+	// check if member cluster number meets requirements
+	if len(clusters.Items) < MinimumMemberCluster {
+		return false, fmt.Errorf("needs at lease %d member cluster to run, but got: %d", MinimumMemberCluster, len(clusters.Items))
+	}
+
+	// check if all member cluster status is ready
+	for _, cluster := range clusters.Items {
+		if !util.IsMemberClusterReady(&cluster) {
+			return false, fmt.Errorf("cluster %s not ready", cluster.GetName())
+		}
+	}
+
+	klog.Infof("Got %d member cluster and all in ready state.", len(clusters.Items))
+	return true, nil
+}