diff --git a/pkg/resourceinterpreter/defaultinterpreter/prune/prune.go b/pkg/resourceinterpreter/defaultinterpreter/prune/prune.go
index 9ac31ba0b..3710f9d4d 100644
--- a/pkg/resourceinterpreter/defaultinterpreter/prune/prune.go
+++ b/pkg/resourceinterpreter/defaultinterpreter/prune/prune.go
@@ -14,7 +14,7 @@ import (
 
 // RemoveIrrelevantField used to remove fields that generated by kube-apiserver and no need(or can't) propagate to
 // member clusters.
-func RemoveIrrelevantField(workload *unstructured.Unstructured) error {
+func RemoveIrrelevantField(workload *unstructured.Unstructured, extraHooks ...func(*unstructured.Unstructured)) error {
 	// populated by the kubernetes.
 	unstructured.RemoveNestedField(workload.Object, "metadata", "creationTimestamp")
 
@@ -63,9 +63,10 @@ func RemoveIrrelevantField(workload *unstructured.Unstructured) error {
 		if err != nil {
 			return err
 		}
-
 		if job.Spec.ManualSelector == nil || !*job.Spec.ManualSelector {
-			return removeGenerateSelectorOfJob(workload)
+			if err = removeGenerateSelectorOfJob(workload); err != nil {
+				return err
+			}
 		}
 	}
 
@@ -83,6 +84,9 @@ func RemoveIrrelevantField(workload *unstructured.Unstructured) error {
 		}
 	}
 
+	for i := range extraHooks {
+		extraHooks[i](workload)
+	}
 	return nil
 }
 
@@ -121,3 +125,16 @@ func removeGenerateSelectorOfJob(workload *unstructured.Unstructured) error {
 	}
 	return nil
 }
+
+// RemoveJobTTLSeconds removes the '.spec.ttlSecondsAfterFinished' from a Job.
+// The reason for removing it is that the Job propagated by Karmada probably be automatically deleted
+// from member clusters(by 'ttl-after-finished' controller in member clusters). That will cause a conflict if
+// Karmada tries to re-create it. See https://github.com/karmada-io/karmada/issues/2197 for more details.
+//
+// It is recommended to enable the `ttl-after-finished` controller in the Karmada control plane.
+// See https://karmada.io/docs/administrator/configuration/configure-controllers#ttl-after-finished for more details.
+func RemoveJobTTLSeconds(workload *unstructured.Unstructured) {
+	if workload.GetKind() == util.JobKind {
+		unstructured.RemoveNestedField(workload.Object, "spec", "ttlSecondsAfterFinished")
+	}
+}
diff --git a/pkg/webhook/work/mutating.go b/pkg/webhook/work/mutating.go
index 6dd8da8b3..c6882de16 100644
--- a/pkg/webhook/work/mutating.go
+++ b/pkg/webhook/work/mutating.go
@@ -43,7 +43,7 @@ func (a *MutatingAdmission) Handle(ctx context.Context, req admission.Request) a
 			return admission.Errored(http.StatusInternalServerError, err)
 		}
 
-		err = prune.RemoveIrrelevantField(workloadObj)
+		err = prune.RemoveIrrelevantField(workloadObj, prune.RemoveJobTTLSeconds)
 		if err != nil {
 			klog.Errorf("Failed to remove irrelevant field for work(%s): %v", work.Name, err)
 			return admission.Errored(http.StatusInternalServerError, err)