diff --git a/.github/workflows/dockerhub-latest-image.yml b/.github/workflows/dockerhub-latest-image.yml
index 4c482d382..24bc2ff7e 100644
--- a/.github/workflows/dockerhub-latest-image.yml
+++ b/.github/workflows/dockerhub-latest-image.yml
@@ -12,6 +12,9 @@ jobs:
     if: ${{ github.repository == 'karmada-io/karmada' && github.ref == 'refs/heads/master' }}
     strategy:
       matrix:
+        arch:
+          - amd64
+          - arm64
         target:
           - karmada-controller-manager
           - karmada-scheduler
@@ -46,4 +49,8 @@ jobs:
       - name: build and publish images
         env:
           VERSION: latest
-        run: make mp-image-${{ matrix.target }}
+          GOARCH: ${{ matrix.arch }}
+        # When we build binary for multiple platform, `go build` may be skipped as `$(SOURCES)` unchanged.
+        # So we clean the binary at first, and force to run `go build`.
+        # See https://github.com/karmada-io/karmada/pull/1649#issuecomment-1107959879 for more info.
+        run: make clean mp-image-${{ matrix.target }}
diff --git a/.github/workflows/dockerhub-released-image.yml b/.github/workflows/dockerhub-released-image.yml
index 0246f5716..e0209ed90 100644
--- a/.github/workflows/dockerhub-released-image.yml
+++ b/.github/workflows/dockerhub-released-image.yml
@@ -8,6 +8,9 @@ jobs:
     name: publish to DockerHub
     strategy:
       matrix:
+        arch:
+          - amd64
+          - arm64
         target:
           - karmada-controller-manager
           - karmada-scheduler
@@ -42,4 +45,8 @@ jobs:
       - name: build and publish images
         env: 
           VERSION: ${{ github.ref_name }}
-        run: make mp-image-${{ matrix.target }}
+          GOARCH: ${{ matrix.arch }}
+        # When we build binary for multiple platform, `go build` may be skipped as `$(SOURCES)` unchanged.
+        # So we clean the binary at first, and force to run `go build`.
+        # See https://github.com/karmada-io/karmada/pull/1649#issuecomment-1107959879 for more info.
+        run: make clean mp-image-${{ matrix.target }}
diff --git a/Makefile b/Makefile
index 90e942a93..bba8ab274 100644
--- a/Makefile
+++ b/Makefile
@@ -39,61 +39,61 @@ endif
 all: karmada-aggregated-apiserver karmada-controller-manager karmada-scheduler karmada-descheduler karmadactl kubectl-karmada karmada-webhook karmada-agent karmada-scheduler-estimator karmada-interpreter-webhook-example
 
 karmada-aggregated-apiserver: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-aggregated-apiserver \
 		cmd/aggregated-apiserver/main.go
 
 karmada-controller-manager: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-controller-manager \
 		cmd/controller-manager/controller-manager.go
 
 karmada-scheduler: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-scheduler \
 		cmd/scheduler/main.go
 
 karmada-descheduler: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-descheduler \
 		cmd/descheduler/main.go
 
 karmadactl: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmadactl \
 		cmd/karmadactl/karmadactl.go
 
 kubectl-karmada: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o kubectl-karmada \
 		cmd/kubectl-karmada/kubectl-karmada.go
 
 karmada-webhook: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-webhook \
 		cmd/webhook/main.go
 
 karmada-agent: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-agent \
 		cmd/agent/main.go
 
 karmada-scheduler-estimator: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-scheduler-estimator \
 		cmd/scheduler-estimator/main.go
 
 karmada-interpreter-webhook-example: $(SOURCES)
-	CGO_ENABLED=0 GOOS=$(GOOS) go build \
+	CGO_ENABLED=0 GOOS=$(GOOS) GOARCH=$(GOARCH) go build \
 		-ldflags $(LDFLAGS) \
 		-o karmada-interpreter-webhook-example \
 		examples/customresourceinterpreter/webhook/main.go