diff --git a/pkg/apis/work/v1alpha2/well_known_labels.go b/pkg/apis/work/v1alpha2/well_known_labels.go
index a96a4d71c..5588d6dfc 100644
--- a/pkg/apis/work/v1alpha2/well_known_labels.go
+++ b/pkg/apis/work/v1alpha2/well_known_labels.go
@@ -26,3 +26,17 @@ const (
 	// WorkNameLabel is added to objects to specify associated Work's name.
 	WorkNameLabel = "work.karmada.io/name"
 )
+
+// Define resource conflict resolution
+const (
+	// ResourceConflictResolutionAnnotation is added to the resource template to specify how to resolve the conflict
+	// in case of resource already existing in member clusters.
+	// The valid value is:
+	//   - overwrite: always overwrite the resource if already exist. The resource will be overwritten with the
+	//     configuration from control plane.
+	// Note: Propagation of the resource template without this annotation will fail in case of already exists.
+	ResourceConflictResolutionAnnotation = "work.karmada.io/conflict-resolution"
+
+	// ResourceConflictResolutionOverwrite is the value of ResourceConflictResolutionAnnotation, indicating the overwrite strategy.
+	ResourceConflictResolutionOverwrite = "overwrite"
+)
diff --git a/pkg/util/annotation.go b/pkg/util/annotation.go
index 53e8f07a8..dd8c0556d 100644
--- a/pkg/util/annotation.go
+++ b/pkg/util/annotation.go
@@ -21,3 +21,11 @@ func MergeAnnotations(dst *unstructured.Unstructured, src *unstructured.Unstruct
 		MergeAnnotation(dst, key, value)
 	}
 }
+
+// GetAnnotationValue retrieves the value via 'annotationKey' if exist, otherwise returns an empty string.
+func GetAnnotationValue(annotations map[string]string, annotationKey string) string {
+	if annotations == nil {
+		return ""
+	}
+	return annotations[annotationKey]
+}
diff --git a/pkg/util/objectwatcher/objectwatcher.go b/pkg/util/objectwatcher/objectwatcher.go
index e19b99e33..e1ee454aa 100644
--- a/pkg/util/objectwatcher/objectwatcher.go
+++ b/pkg/util/objectwatcher/objectwatcher.go
@@ -16,6 +16,7 @@ import (
 
 	configv1alpha1 "github.com/karmada-io/karmada/pkg/apis/config/v1alpha1"
 	workv1alpha1 "github.com/karmada-io/karmada/pkg/apis/work/v1alpha1"
+	workv1alpha2 "github.com/karmada-io/karmada/pkg/apis/work/v1alpha2"
 	"github.com/karmada-io/karmada/pkg/resourceinterpreter"
 	"github.com/karmada-io/karmada/pkg/util"
 	"github.com/karmada-io/karmada/pkg/util/restmapper"
@@ -84,12 +85,23 @@ func (o *objectWatcherImpl) Create(clusterName string, desireObj *unstructured.U
 				return fmt.Errorf("failed to get exist resource(kind=%s, %s/%s) in cluster %v: %v", desireObj.GetKind(), desireObj.GetNamespace(), desireObj.GetName(), clusterName, err)
 			}
 
-			// Avoid updating resources that not managed by karmada.
-			if util.GetLabelValue(desireObj.GetLabels(), workv1alpha1.WorkNameLabel) != util.GetLabelValue(existObj.GetLabels(), workv1alpha1.WorkNameLabel) {
-				return fmt.Errorf("resource(kind=%s, %s/%s) already exist in cluster %v but not managed by karamda", desireObj.GetKind(), desireObj.GetNamespace(), desireObj.GetName(), clusterName)
+			// If the existing resource is managed by Karmada, then just update it.
+			if util.GetLabelValue(desireObj.GetLabels(), workv1alpha1.WorkNameLabel) == util.GetLabelValue(existObj.GetLabels(), workv1alpha1.WorkNameLabel) {
+				return o.Update(clusterName, desireObj, existObj)
 			}
 
-			return o.Update(clusterName, desireObj, existObj)
+			// The existing resource is not managed by Karmada, then we should consult conflict resolution instruction in annotation.
+			switch util.GetAnnotationValue(desireObj.GetAnnotations(), workv1alpha2.ResourceConflictResolutionAnnotation) {
+			case workv1alpha2.ResourceConflictResolutionOverwrite:
+				klog.Infof("Overwriting the resource(kind=%s, %s/%s) as %s=%s", desireObj.GetKind(), desireObj.GetNamespace(), desireObj.GetName(),
+					workv1alpha2.ResourceConflictResolutionAnnotation, workv1alpha2.ResourceConflictResolutionOverwrite)
+				return o.Update(clusterName, desireObj, existObj)
+			default:
+				// The existing resource is not managed by Karmada, and no conflict resolution found, avoid updating the existing resource by default.
+				return fmt.Errorf("resource(kind=%s, %s/%s) already exist in cluster %v and the %s strategy value is empty, karmada will not manage this resource",
+					desireObj.GetKind(), desireObj.GetNamespace(), desireObj.GetName(), clusterName, workv1alpha2.ResourceConflictResolutionAnnotation,
+				)
+			}
 		}
 		klog.Errorf("Failed to create resource(kind=%s, %s/%s) in cluster %s, err is %v ", desireObj.GetKind(), desireObj.GetNamespace(), desireObj.GetName(), clusterName, err)
 		return err