diff --git a/tests/e2e/pkg/tester/skip_regex.go b/tests/e2e/pkg/tester/skip_regex.go
new file mode 100644
index 0000000000..0c58193dd0
--- /dev/null
+++ b/tests/e2e/pkg/tester/skip_regex.go
@@ -0,0 +1,93 @@
+/*
+Copyright 2021 The Kubernetes Authors.
+
+Licensed under the Apache License, Version 2.0 (the "License");
+you may not use this file except in compliance with the License.
+You may obtain a copy of the License at
+
+    http://www.apache.org/licenses/LICENSE-2.0
+
+Unless required by applicable law or agreed to in writing, software
+distributed under the License is distributed on an "AS IS" BASIS,
+WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+See the License for the specific language governing permissions and
+limitations under the License.
+*/
+
+package tester
+
+import (
+	"regexp"
+	"strings"
+)
+
+const (
+	skipRegexBase = "[Slow]|[Serial]|[Disruptive]|[Flaky]|[Feature:.+]|[HPA]|[Driver:.nfs]|Dashboard|RuntimeClass|RuntimeHandler"
+)
+
+func (t *Tester) setSkipRegexFlag() error {
+
+	// Temporarily removing for testing in the PR
+	// TODO: uncomment before merging
+	/*if t.SkipRegex != "" {
+		return nil
+	}*/
+
+	cluster, err := t.getKopsCluster()
+	if err != nil {
+		return err
+	}
+
+	skipRegex := skipRegexBase
+
+	networking := cluster.Spec.Networking
+	switch {
+	case networking.Kubenet != nil, networking.Canal != nil, networking.Weave != nil, networking.Cilium != nil:
+		skipRegex += "|Services.*rejected.*endpoints"
+	}
+	if networking.Cilium != nil {
+		// https://github.com/cilium/cilium/issues/10002
+		skipRegex += "|TCP.CLOSE_WAIT"
+		// https://github.com/cilium/cilium/issues/15361
+		skipRegex += "|external.IP.is.not.assigned.to.a.node"
+		// https://github.com/cilium/cilium/issues/14287
+		skipRegex += "|same.port.number.but.different.protocols|same.hostPort.but.different.hostIP.and.protocol"
+	} else if networking.Calico != nil {
+		skipRegex += "|Services.*functioning.*NodePort"
+	} else if networking.Kuberouter != nil {
+		skipRegex += "|load-balancer|hairpin|affinity\\stimeout|service\\.kubernetes\\.io|CLOSE_WAIT"
+	} else if networking.Kubenet != nil {
+		skipRegex += "|Services.*affinity"
+	}
+
+	if cluster.Spec.CloudProvider == "aws" {
+		if strings.Contains(cluster.Spec.KubernetesVersion, "v1.21.") {
+			// TODO(rifelpet): Remove once k8s tags has been created that include
+			// https://github.com/kubernetes/kubernetes/pull/101443
+			skipRegex += "|Invalid.AWS.KMS.key"
+		}
+		if strings.Contains(cluster.Spec.KubernetesVersion, "v1.22.") {
+			// TODO(rifelpet): Remove once volume limits tests have been fixed
+			// https://github.com/kubernetes/kubernetes/issues/79660#issuecomment-854884112
+			skipRegex += "|Volume.limits.should.verify.that.all.nodes.have.volume.limits"
+		}
+	}
+
+	igs, err := t.getKopsInstanceGroups()
+	if err != nil {
+		return err
+	}
+	for _, ig := range igs {
+		if strings.Contains(ig.Spec.Image, "arm64") {
+			skipRegex += "|Simple.pod.should.handle.in-cluster.config"
+			break
+		}
+	}
+
+	// Ensure it is valid regex
+	if _, err := regexp.Compile(skipRegex); err != nil {
+		return err
+	}
+	t.SkipRegex = skipRegex
+	return nil
+}
diff --git a/tests/e2e/pkg/tester/tester.go b/tests/e2e/pkg/tester/tester.go
index 792f270beb..877dd3a775 100644
--- a/tests/e2e/pkg/tester/tester.go
+++ b/tests/e2e/pkg/tester/tester.go
@@ -351,6 +351,10 @@ func (t *Tester) execute() error {
 		return err
 	}
 
+	if err := t.setSkipRegexFlag(); err != nil {
+		return err
+	}
+
 	return t.Test()
 }