diff --git a/src/OpenTelemetry.Exporter.InMemory/.publicApi/net452/PublicAPI.Unshipped.txt b/src/OpenTelemetry.Exporter.InMemory/.publicApi/net452/PublicAPI.Unshipped.txt
deleted file mode 100644
index e69de29bb..000000000
diff --git a/src/OpenTelemetry.Exporter.InMemory/.publicApi/net46/PublicAPI.Unshipped.txt b/src/OpenTelemetry.Exporter.InMemory/.publicApi/net46/PublicAPI.Unshipped.txt
deleted file mode 100644
index e69de29bb..000000000
diff --git a/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md b/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
index 22c1d1daa..d6739e1fc 100644
--- a/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
@@ -9,6 +9,9 @@ please check the latest changes
 
 ## Unreleased
 
+* Removes support for .NET Framework 4.5.2 and 4.6. The minimum .NET Framework version
+  supported is .NET 4.6.1. ([#2138](https://github.com/open-telemetry/opentelemetry-dotnet/issues/2138))
+
 ## 1.1.0
 
 Released 2021-Jul-12
diff --git a/src/OpenTelemetry.Exporter.InMemory/InMemoryExporterLoggingExtensions.cs b/src/OpenTelemetry.Exporter.InMemory/InMemoryExporterLoggingExtensions.cs
index dce341412..c500949d6 100644
--- a/src/OpenTelemetry.Exporter.InMemory/InMemoryExporterLoggingExtensions.cs
+++ b/src/OpenTelemetry.Exporter.InMemory/InMemoryExporterLoggingExtensions.cs
@@ -14,7 +14,6 @@
 // limitations under the License.
 // </copyright>
 
-#if NET461 || NETSTANDARD2_0
 using System;
 using System.Collections.Generic;
 using OpenTelemetry.Exporter;
@@ -39,4 +38,3 @@ namespace OpenTelemetry.Logs
         }
     }
 }
-#endif
diff --git a/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj b/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
index 896a0108e..8eb494b7f 100644
--- a/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
+++ b/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>netstandard2.0;net452;net46;net461</TargetFrameworks>
+    <TargetFrameworks>netstandard2.0;net461</TargetFrameworks>
     <Description>In-memory exporter for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags)</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/test/OpenTelemetry.Tests/Logs/LogRecordTest.cs b/test/OpenTelemetry.Tests/Logs/LogRecordTest.cs
index 6b108e8b7..3e733bc37 100644
--- a/test/OpenTelemetry.Tests/Logs/LogRecordTest.cs
+++ b/test/OpenTelemetry.Tests/Logs/LogRecordTest.cs
@@ -14,7 +14,7 @@
 // limitations under the License.
 // </copyright>
 
-#if !NET452 && !NET46
+#if !NET461
 #if NETCOREAPP2_1
 using Microsoft.Extensions.DependencyInjection;
 #endif
diff --git a/test/OpenTelemetry.Tests/OpenTelemetry.Tests.csproj b/test/OpenTelemetry.Tests/OpenTelemetry.Tests.csproj
index 4bce77a0f..7a790bf34 100644
--- a/test/OpenTelemetry.Tests/OpenTelemetry.Tests.csproj
+++ b/test/OpenTelemetry.Tests/OpenTelemetry.Tests.csproj
@@ -2,7 +2,7 @@
   <PropertyGroup>
     <Description>Unit test project for OpenTelemetry</Description>
     <TargetFrameworks>netcoreapp2.1;netcoreapp3.1;net5.0</TargetFrameworks>
-    <TargetFrameworks Condition="$(OS) == 'Windows_NT'">$(TargetFrameworks);net46;net452</TargetFrameworks>
+    <TargetFrameworks Condition="$(OS) == 'Windows_NT'">$(TargetFrameworks);net461</TargetFrameworks>
     <NoWarn>$(NoWarn),CS0618</NoWarn>
   </PropertyGroup>
 
@@ -16,7 +16,7 @@
     <PackageReference Include="Microsoft.Extensions.DependencyInjection" Version="2.1.1" />
   </ItemGroup>
 
-  <ItemGroup Condition="'$(TargetFramework)' != 'net452' And '$(TargetFramework)' != 'net46' And '$(TargetFramework)' != 'netcoreapp2.1'">
+  <ItemGroup Condition="'$(TargetFramework)' != 'netcoreapp2.1'">
     <PackageReference Include="Microsoft.Extensions.Logging" Version="$(MicrosoftExtensionsLoggingPkgVer)" />
   </ItemGroup>