diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5194b3635..4bf29bc4b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -21,6 +21,7 @@ This project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.htm
 - Add info and debug logging to the metric SDK. (#4315)
 - The `go.opentelemetry.io/otel/semconv/v1.21.0` package.
   The package contains semantic conventions from the `v1.21.0` version of the OpenTelemetry Semantic Conventions. (#4362)
+- Accept 201 to 299 HTTP status as success in `go.opentelemetry.io/otel/exporters/otlp/otlpmetric/otlpmetrichttp` and `go.opentelemetry.io/otel/exporters/otlp/otlptrace/otlptracehttp`. (#4365)
 - Document the `Temporality` and `Aggregation` methods of the `"go.opentelemetry.io/otel/sdk/metric".Exporter"` need to be concurrent safe. (#4381)
 - Expand the set of units supported by the prometheus exporter, and don't add unit suffixes if they are already present in `go.opentelemetry.op/otel/exporters/prometheus` (#4374)
 
diff --git a/exporters/otlp/otlpmetric/internal/otest/client.go b/exporters/otlp/otlpmetric/internal/otest/client.go
index f58aa99ae..a315869c1 100644
--- a/exporters/otlp/otlpmetric/internal/otest/client.go
+++ b/exporters/otlp/otlpmetric/internal/otest/client.go
@@ -272,6 +272,34 @@ func RunClientTests(f ClientFactory) func(*testing.T) {
 			want := fmt.Sprintf("%s (%d metric data points rejected)", msg, n)
 			assert.ErrorContains(t, errs[0], want)
 		})
+
+		t.Run("Other HTTP success", func(t *testing.T) {
+			for code := 201; code <= 299; code++ {
+				t.Run(fmt.Sprintf("status_%d", code), func(t *testing.T) {
+					rCh := make(chan ExportResult, 1)
+					rCh <- ExportResult{
+						ResponseStatus: code,
+					}
+
+					ctx := context.Background()
+					client, _ := f(rCh)
+					defer func() {
+						assert.NoError(t, client.Shutdown(ctx))
+					}()
+
+					defer func(orig otel.ErrorHandler) {
+						otel.SetErrorHandler(orig)
+					}(otel.GetErrorHandler())
+
+					errs := []error{}
+					eh := otel.ErrorHandlerFunc(func(e error) { errs = append(errs, e) })
+					otel.SetErrorHandler(eh)
+
+					assert.NoError(t, client.UploadMetrics(ctx, nil))
+					assert.Equal(t, 0, len(errs))
+				})
+			}
+		})
 	}
 }
 
diff --git a/exporters/otlp/otlpmetric/internal/otest/collector.go b/exporters/otlp/otlpmetric/internal/otest/collector.go
index 95e757dae..34756f4cc 100644
--- a/exporters/otlp/otlpmetric/internal/otest/collector.go
+++ b/exporters/otlp/otlpmetric/internal/otest/collector.go
@@ -50,8 +50,9 @@ type Collector interface {
 }
 
 type ExportResult struct {
-	Response *collpb.ExportMetricsServiceResponse
-	Err      error
+	Response       *collpb.ExportMetricsServiceResponse
+	ResponseStatus int
+	Err            error
 }
 
 // Storage stores uploaded OTLP metric data in their proto form.
@@ -376,7 +377,11 @@ func (c *HTTPCollector) respond(w http.ResponseWriter, resp ExportResult) {
 	}
 
 	w.Header().Set("Content-Type", "application/x-protobuf")
-	w.WriteHeader(http.StatusOK)
+	if resp.ResponseStatus != 0 {
+		w.WriteHeader(resp.ResponseStatus)
+	} else {
+		w.WriteHeader(http.StatusOK)
+	}
 	if resp.Response == nil {
 		_, _ = w.Write(emptyExportMetricsServiceResponse)
 	} else {
diff --git a/exporters/otlp/otlpmetric/otlpmetrichttp/client.go b/exporters/otlp/otlpmetric/otlpmetrichttp/client.go
index ac7023c7a..33f5474c1 100644
--- a/exporters/otlp/otlpmetric/otlpmetrichttp/client.go
+++ b/exporters/otlp/otlpmetric/otlpmetrichttp/client.go
@@ -153,8 +153,8 @@ func (c *client) UploadMetrics(ctx context.Context, protoMetrics *metricpb.Resou
 		}
 
 		var rErr error
-		switch resp.StatusCode {
-		case http.StatusOK:
+		switch sc := resp.StatusCode; {
+		case sc >= 200 && sc <= 299:
 			// Success, do not retry.
 
 			// Read the partial success message, if any.
@@ -179,8 +179,7 @@ func (c *client) UploadMetrics(ctx context.Context, protoMetrics *metricpb.Resou
 				}
 			}
 			return nil
-		case http.StatusTooManyRequests,
-			http.StatusServiceUnavailable:
+		case sc == http.StatusTooManyRequests, sc == http.StatusServiceUnavailable:
 			// Retry-able failure.
 			rErr = newResponseError(resp.Header)
 
diff --git a/exporters/otlp/otlptrace/otlptracehttp/client.go b/exporters/otlp/otlptrace/otlptracehttp/client.go
index fe8afc240..3a3cfec0c 100644
--- a/exporters/otlp/otlptrace/otlptracehttp/client.go
+++ b/exporters/otlp/otlptrace/otlptracehttp/client.go
@@ -164,8 +164,8 @@ func (d *client) UploadTraces(ctx context.Context, protoSpans []*tracepb.Resourc
 			}()
 		}
 
-		switch resp.StatusCode {
-		case http.StatusOK:
+		switch sc := resp.StatusCode; {
+		case sc >= 200 && sc <= 299:
 			// Success, do not retry.
 			// Read the partial success message, if any.
 			var respData bytes.Buffer
@@ -190,7 +190,7 @@ func (d *client) UploadTraces(ctx context.Context, protoSpans []*tracepb.Resourc
 			}
 			return nil
 
-		case http.StatusTooManyRequests, http.StatusServiceUnavailable:
+		case sc == http.StatusTooManyRequests, sc == http.StatusServiceUnavailable:
 			// Retry-able failures.  Drain the body to reuse the connection.
 			if _, err := io.Copy(io.Discard, resp.Body); err != nil {
 				otel.Handle(err)
diff --git a/exporters/otlp/otlptrace/otlptracehttp/client_test.go b/exporters/otlp/otlptrace/otlptracehttp/client_test.go
index 279d8ada3..2020b1505 100644
--- a/exporters/otlp/otlptrace/otlptracehttp/client_test.go
+++ b/exporters/otlp/otlptrace/otlptracehttp/client_test.go
@@ -401,3 +401,34 @@ func TestPartialSuccess(t *testing.T) {
 	require.Contains(t, errs[0].Error(), "partially successful")
 	require.Contains(t, errs[0].Error(), "2 spans rejected")
 }
+
+func TestOtherHTTPSuccess(t *testing.T) {
+	for code := 201; code <= 299; code++ {
+		t.Run(fmt.Sprintf("status_%d", code), func(t *testing.T) {
+			mcCfg := mockCollectorConfig{
+				InjectHTTPStatus: []int{code},
+			}
+			mc := runMockCollector(t, mcCfg)
+			defer mc.MustStop(t)
+			driver := otlptracehttp.NewClient(
+				otlptracehttp.WithEndpoint(mc.Endpoint()),
+				otlptracehttp.WithInsecure(),
+			)
+			ctx := context.Background()
+			exporter, err := otlptrace.New(ctx, driver)
+			require.NoError(t, err)
+			defer func() {
+				assert.NoError(t, exporter.Shutdown(context.Background()))
+			}()
+
+			errs := []error{}
+			otel.SetErrorHandler(otel.ErrorHandlerFunc(func(err error) {
+				errs = append(errs, err)
+			}))
+			err = exporter.ExportSpans(ctx, otlptracetest.SingleReadOnlySpan())
+			assert.NoError(t, err)
+
+			assert.Equal(t, 0, len(errs))
+		})
+	}
+}