diff --git a/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/DefaultConnectionPoolInstrumentation.java b/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/DefaultConnectionPoolInstrumentation.java
new file mode 100644
index 0000000000..a7e5d78a5b
--- /dev/null
+++ b/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/DefaultConnectionPoolInstrumentation.java
@@ -0,0 +1,42 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+package io.opentelemetry.javaagent.instrumentation.mongo.v4_0;
+
+import static net.bytebuddy.matcher.ElementMatchers.named;
+import static net.bytebuddy.matcher.ElementMatchers.takesArgument;
+
+import com.mongodb.internal.async.SingleResultCallback;
+import io.opentelemetry.javaagent.extension.instrumentation.TypeInstrumentation;
+import io.opentelemetry.javaagent.extension.instrumentation.TypeTransformer;
+import io.opentelemetry.javaagent.instrumentation.api.Java8BytecodeBridge;
+import net.bytebuddy.asm.Advice;
+import net.bytebuddy.description.type.TypeDescription;
+import net.bytebuddy.matcher.ElementMatcher;
+
+public class DefaultConnectionPoolInstrumentation implements TypeInstrumentation {
+  @Override
+  public ElementMatcher<TypeDescription> typeMatcher() {
+    return named("com.mongodb.internal.connection.DefaultConnectionPool");
+  }
+
+  @Override
+  public void transform(TypeTransformer transformer) {
+    // instrumentation needed since 4.3.0-beta3
+    transformer.applyAdviceToMethod(
+        named("getAsync")
+            .and(takesArgument(0, named("com.mongodb.internal.async.SingleResultCallback"))),
+        this.getClass().getName() + "$SingleResultCallbackAdvice");
+  }
+
+  public static class SingleResultCallbackAdvice {
+
+    @Advice.OnMethodEnter(suppress = Throwable.class)
+    public static void wrapCallback(
+        @Advice.Argument(value = 0, readOnly = false) SingleResultCallback<Object> callback) {
+      callback = new SingleResultCallbackWrapper(Java8BytecodeBridge.currentContext(), callback);
+    }
+  }
+}
diff --git a/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/MongoClientInstrumentationModule.java b/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/MongoClientInstrumentationModule.java
index 949b6b0e25..4d32ec8475 100644
--- a/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/MongoClientInstrumentationModule.java
+++ b/instrumentation/mongo/mongo-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/mongo/v4_0/MongoClientInstrumentationModule.java
@@ -24,6 +24,7 @@ public class MongoClientInstrumentationModule extends InstrumentationModule {
     return asList(
         new MongoClientSettingsBuilderInstrumentation(),
         new InternalStreamConnectionInstrumentation(),
-        new BaseClusterInstrumentation());
+        new BaseClusterInstrumentation(),
+        new DefaultConnectionPoolInstrumentation());
   }
 }