diff --git a/tox.ini b/tox.ini
index ed4122a3c..4b9ed9047 100644
--- a/tox.ini
+++ b/tox.ini
@@ -52,6 +52,11 @@ envlist =
     py3{4,5,6,7,8}-test-instrumentation-elasticsearch{2,5,6,7}
     pypy3-test-instrumentation-elasticsearch{2,5,6,7}
 
+    ; opentelemetry-instrumentation-fastapi
+    ; fastapi only supports 3.6 and above.
+    py3{6,7,8}-test-instrumentation-fastapi
+    pypy3-test-instrumentation-fastapi
+
     ; opentelemetry-ext-flask
     py3{4,5,6,7,8}-test-instrumentation-flask
     pypy3-test-instrumentation-flask
@@ -187,8 +192,7 @@ deps =
   elasticsearch7: elasticsearch-dsl>=7.0,<8.0
   elasticsearch7: elasticsearch>=7.0,<8.0
 
-setenv =
-  mypy: MYPYPATH={toxinidir}/opentelemetry-api/src/
+setenv = mypy: MYPYPATH={toxinidir}/opentelemetry-api/src/
 
 changedir =
   test-core-api: opentelemetry-api/tests
@@ -215,6 +219,7 @@ changedir =
   test-instrumentation-wsgi: ext/opentelemetry-ext-wsgi/tests
   test-instrumentation-boto: ext/opentelemetry-ext-boto/tests
   test-instrumentation-botocore: ext/opentelemetry-ext-botocore/tests
+  test-instrumentation-fastapi: ext/opentelemetry-instrumentation-fastapi/tests
   test-instrumentation-flask: ext/opentelemetry-ext-flask/tests
   test-instrumentation-example-app: docs/examples/opentelemetry-example-app/tests
   test-instrumentation-sqlalchemy: ext/opentelemetry-ext-sqlalchemy/tests
@@ -236,7 +241,7 @@ changedir =
 
 commands_pre =
 ; Install without -e to test the actual installation
-  py3{4,5,6,7}: python -m pip install -U pip setuptools wheel
+  py3{4,5,6,7,8}: python -m pip install -U pip setuptools wheel
 ; Install common packages for all the tests. These are not needed in all the
 ; cases but it saves a lot of boilerplate in this file.
   test: pip install {toxinidir}/opentelemetry-api {toxinidir}/opentelemetry-sdk {toxinidir}/tests/util
@@ -252,9 +257,8 @@ commands_pre =
 
   grpc: pip install {toxinidir}/ext/opentelemetry-ext-grpc[test]
 
-  wsgi,flask,django,asgi,pyramid,starlette: pip install {toxinidir}/tests/util
   wsgi,flask,django,pyramid: pip install {toxinidir}/ext/opentelemetry-ext-wsgi
-  asgi,starlette: pip install {toxinidir}/ext/opentelemetry-ext-asgi
+  asgi,starlette,fastapi: pip install {toxinidir}/ext/opentelemetry-ext-asgi
 
   asyncpg: pip install {toxinidir}/ext/opentelemetry-ext-asyncpg
 
@@ -269,6 +273,8 @@ commands_pre =
 
   django: pip install {toxinidir}/ext/opentelemetry-ext-django[test]
 
+  fastapi: pip install {toxinidir}/ext/opentelemetry-instrumentation-fastapi[test]
+
   mysql: pip install {toxinidir}/ext/opentelemetry-ext-dbapi {toxinidir}/ext/opentelemetry-ext-mysql[test]
 
   opencensusexporter: pip install {toxinidir}/ext/opentelemetry-ext-opencensusexporter