diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 84cbecace..515fdf433 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -6,7 +6,6 @@ jobs:
   build:
     env:
       # We use these variables to convert between tox and GHA version literals
-      py34: 3.4
       py35: 3.5
       py36: 3.6
       py37: 3.7
@@ -16,7 +15,7 @@ jobs:
     strategy:
       fail-fast: false  # ensures the entire test matrix is run, even if one permutation fails
       matrix:
-        python-version: [ py34, py35, py36, py37, py38, pypy3 ]
+        python-version: [ py35, py36, py37, py38, pypy3 ]
         package: ["instrumentation", "core", "exporter"]
         os: [ ubuntu-latest ]
         include:
diff --git a/tox.ini b/tox.ini
index 0fbaabce8..057562907 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,15 +5,15 @@ envlist =
     ; Environments are organized by individual package, allowing
     ; for specifying supported Python versions per package.
     ; opentelemetry-api
-    py3{4,5,6,7,8}-test-core-api
+    py3{5,6,7,8}-test-core-api
     pypy3-test-core-api
 
     ; opentelemetry-proto
-    py3{4,5,6,7,8}-test-core-proto
+    py3{5,6,7,8}-test-core-proto
     pypy3-test-core-proto
 
     ; opentelemetry-sdk
-    py3{4,5,6,7,8}-test-core-sdk
+    py3{5,6,7,8}-test-core-sdk
     pypy3-test-core-sdk
 
     ; opentelemetry-instrumentation
@@ -21,11 +21,11 @@ envlist =
     pypy3-test-core-instrumentation
 
     ; docs/getting-started
-    py3{4,5,6,7,8}-test-core-getting-started
+    py3{5,6,7,8}-test-core-getting-started
     pypy3-test-core-getting-started
 
     ; opentelemetry-example-app
-    py3{4,5,6,7,8}-test-instrumentation-example-app
+    py3{5,6,7,8}-test-instrumentation-example-app
     pypy3-test-instrumentation-example-app
 
     ; opentelemetry-instrumentation-aiohttp-client
@@ -41,11 +41,11 @@ envlist =
     pypy3-test-instrumentation-botocore
 
     ; opentelemetry-instrumentation-django
-    py3{4,5,6,7,8}-test-instrumentation-django
+    py3{5,6,7,8}-test-instrumentation-django
     pypy3-test-instrumentation-django
 
     ; opentelemetry-instrumentation-dbapi
-    py3{4,5,6,7,8}-test-instrumentation-dbapi
+    py3{5,6,7,8}-test-instrumentation-dbapi
     pypy3-test-instrumentation-dbapi
 
     ; opentelemetry-instrumentation-boto
@@ -53,7 +53,7 @@ envlist =
     pypy3-test-instrumentation-boto
 
     ; opentelemetry-instrumentation-elasticsearch
-    py3{4,5,6,7,8}-test-instrumentation-elasticsearch{2,5,6,7}
+    py3{5,6,7,8}-test-instrumentation-elasticsearch{2,5,6,7}
     pypy3-test-instrumentation-elasticsearch{2,5,6,7}
 
     ; opentelemetry-instrumentation-fastapi
@@ -62,11 +62,11 @@ envlist =
     pypy3-test-instrumentation-fastapi
 
     ; opentelemetry-instrumentation-flask
-    py3{4,5,6,7,8}-test-instrumentation-flask
+    py3{5,6,7,8}-test-instrumentation-flask
     pypy3-test-instrumentation-flask
 
     ; opentelemetry-instrumentation-requests
-    py3{4,5,6,7,8}-test-instrumentation-requests
+    py3{5,6,7,8}-test-instrumentation-requests
     pypy3-test-instrumentation-requests
 
     ; opentelemetry-instrumentation-starlette.
@@ -75,22 +75,22 @@ envlist =
     pypy3-test-instrumentation-starlette
 
     ; opentelemetry-instrumentation-jinja2
-    py3{4,5,6,7,8}-test-instrumentation-jinja2
+    py3{5,6,7,8}-test-instrumentation-jinja2
     pypy3-test-instrumentation-jinja2
 
     ; opentelemetry-exporter-jaeger
-    py3{4,5,6,7,8}-test-exporter-jaeger
+    py3{5,6,7,8}-test-exporter-jaeger
     pypy3-test-exporter-jaeger
 
     ; opentelemetry-exporter-datadog
     py3{5,6,7,8}-test-exporter-datadog
 
     ; opentelemetry-instrumentation-mysql
-    py3{4,5,6,7,8}-test-instrumentation-mysql
+    py3{5,6,7,8}-test-instrumentation-mysql
     pypy3-test-instrumentation-mysql
 
     ; opentelemetry-exporter-opencensus
-    py3{4,5,6,7,8}-test-exporter-opencensus
+    py3{5,6,7,8}-test-exporter-opencensus
     ; exporter-opencensus intentionally excluded from pypy3
 
     ; opentelemetry-exporter-otlp
@@ -98,27 +98,27 @@ envlist =
     ; exporter-otlp intentionally excluded from pypy3
 
     ; opentelemetry-exporter-prometheus
-    py3{4,5,6,7,8}-test-exporter-prometheus
+    py3{5,6,7,8}-test-exporter-prometheus
     pypy3-test-exporter-prometheus
 
     ; opentelemetry-instrumentation-psycopg2
-    py3{4,5,6,7,8}-test-instrumentation-psycopg2
+    py3{5,6,7,8}-test-instrumentation-psycopg2
     ; ext-psycopg2 intentionally excluded from pypy3
 
     ; opentelemetry-instrumentation-pymemcache
-    py3{4,5,6,7,8}-test-instrumentation-pymemcache
+    py3{5,6,7,8}-test-instrumentation-pymemcache
     pypy3-test-instrumentation-pymemcache
 
     ; opentelemetry-instrumentation-pymongo
-    py3{4,5,6,7,8}-test-instrumentation-pymongo
+    py3{5,6,7,8}-test-instrumentation-pymongo
     pypy3-test-instrumentation-pymongo
 
     ; opentelemetry-instrumentation-pymysql
-    py3{4,5,6,7,8}-test-instrumentation-pymysql
+    py3{5,6,7,8}-test-instrumentation-pymysql
     pypy3-test-instrumentation-pymysql
 
     ; opentelemetry-instrumentation-pyramid
-    py3{4,5,6,7,8}-test-instrumentation-pyramid
+    py3{5,6,7,8}-test-instrumentation-pyramid
     pypy3-test-instrumentation-pyramid
 
     ; opentelemetry-instrumentation-asgi
@@ -130,30 +130,30 @@ envlist =
     ; ext-asyncpg intentionally excluded from pypy3
 
     ; opentelemetry-instrumentation-sqlite3
-    py3{4,5,6,7,8}-test-instrumentation-sqlite3
+    py3{5,6,7,8}-test-instrumentation-sqlite3
     pypy3-test-instrumentation-sqlite3
 
     ; opentelemetry-instrumentation-wsgi
-    py3{4,5,6,7,8}-test-instrumentation-wsgi
+    py3{5,6,7,8}-test-instrumentation-wsgi
     pypy3-test-instrumentation-wsgi
 
     ; opentelemetry-exporter-zipkin
-    py3{4,5,6,7,8}-test-exporter-zipkin
+    py3{5,6,7,8}-test-exporter-zipkin
     pypy3-test-exporter-zipkin
 
     ; opentelemetry-opentracing-shim
-    py3{4,5,6,7,8}-test-core-opentracing-shim
+    py3{5,6,7,8}-test-core-opentracing-shim
     pypy3-test-core-opentracing-shim
 
     ; opentelemetry-instrumentation-grpc
     py3{5,6,7,8}-test-instrumentation-grpc
 
     ; opentelemetry-instrumentation-sqlalchemy
-    py3{4,5,6,7,8}-test-instrumentation-sqlalchemy
+    py3{5,6,7,8}-test-instrumentation-sqlalchemy
     pypy3-test-instrumentation-sqlalchemy
 
     ; opentelemetry-instrumentation-redis
-    py3{4,5,6,7,8}-test-instrumentation-redis
+    py3{5,6,7,8}-test-instrumentation-redis
     pypy3-test-instrumentation-redis
 
     ; opentelemetry-instrumentation-celery
@@ -161,7 +161,7 @@ envlist =
     pypy3-test-instrumentation-celery
 
     ; opentelemetry-instrumentation-system-metrics
-    py3{4,5,6,7,8}-test-instrumentation-system-metrics
+    py3{5,6,7,8}-test-instrumentation-system-metrics
     ; instrumentation-system-metrics intentionally excluded from pypy3
     ; known limitation: gc.get_count won't work under pypy
 
@@ -235,7 +235,7 @@ changedir =
 
 commands_pre =
 ; Install without -e to test the actual installation
-  py3{4,5,6,7,8}: python -m pip install -U pip setuptools wheel
+  py3{5,6,7,8}: python -m pip install -U pip setuptools wheel
 ; Install common packages for all the tests. These are not needed in all the
 ; cases but it saves a lot of boilerplate in this file.
   test: pip install {toxinidir}/opentelemetry-api {toxinidir}/opentelemetry-sdk {toxinidir}/tests/util
@@ -337,10 +337,6 @@ commands =
 ; implicit Any due to unfollowed import would result).
   mypyinstalled: mypy --namespace-packages opentelemetry-api/tests/mypysmoke.py --strict
 
-[testenv:py34-test-core-opentracing-shim]
-commands =
-  pytest --ignore-glob='*[asyncio].py'
-
 [testenv:lint]
 basepython: python3.8
 recreate = True