opentelemetry.io/content/en/docs/languages/python/automatic/operator.md

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Using the OpenTelemetry Operator to Inject Auto-Instrumentation	Operator	30	distro mkdir uninstrumented virtualenv

If you run your Python service in Kubernetes, you can take advantage of the OpenTelemetry Operator to inject auto-instrumentation without having to modify each of your services directly. See the OpenTelemetry Operator Auto-instrumentation docs for more details.