diff --git a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
index 68237df3ba..9aa678b41e 100644
--- a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
+++ b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
@@ -130,12 +130,9 @@ public class RegionErrorHandler<RespT> implements ErrorHandler<RespT> {
           BackOffFunction.BackOffFuncType.BoServerBusy,
           new StatusRuntimeException(
               Status.fromCode(Status.Code.UNAVAILABLE).withDescription(error.toString())));
-      return true;
-    } else if (error.hasRegionNotFound()) {
       backOffer.doBackOff(
           BackOffFunction.BackOffFuncType.BoRegionMiss, new GrpcException(error.getMessage()));
-      this.regionManager.onRegionStale(recv.getRegion());
-      return false;
+      return true;
     } else if (error.hasStaleCommand()) {
       // this error is reported from raftstore:
       // command outdated, please try later
diff --git a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
index ba6422a8ec..c47bb85474 100644
--- a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
+++ b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
@@ -272,7 +272,7 @@ public abstract class AbstractRegionStoreClient
     }
     if (originStore == null) {
       originStore = targetStore;
-      if (this.targetStore.getProxyStore() != null && this.timeout < conf.getForwardTimeout()) {
+      if (this.targetStore.getProxyStore() != null) {
         this.timeout = conf.getForwardTimeout();
       }
     }
diff --git a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
index 1148f64ea5..a7af12b85c 100644
--- a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
+++ b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
@@ -86,29 +86,29 @@ public class ConcreteBackOffer implements BackOffer {
   private BackOffFunction createBackOffFunc(BackOffFunction.BackOffFuncType funcType) {
     BackOffFunction backOffFunction = null;
     switch (funcType) {
+      case BoUpdateLeader:
+        backOffFunction = BackOffFunction.create(1, 10, BackOffStrategy.NoJitter);
+        break;
       case BoTxnLockFast:
         backOffFunction = BackOffFunction.create(100, 3000, BackOffStrategy.EqualJitter);
         break;
+      case BoServerBusy:
+        backOffFunction = BackOffFunction.create(2000, 10000, BackOffStrategy.EqualJitter);
+        break;
+      case BoRegionMiss:
+        backOffFunction = BackOffFunction.create(100, 500, BackOffStrategy.NoJitter);
+        break;
       case BoTxnLock:
         backOffFunction = BackOffFunction.create(200, 3000, BackOffStrategy.EqualJitter);
         break;
-      case BoTxnNotFound:
-        backOffFunction = BackOffFunction.create(2, 500, BackOffStrategy.NoJitter);
-        break;
-      case BoServerBusy:
-        backOffFunction = BackOffFunction.create(40, 5120, BackOffStrategy.EqualJitter);
-        break;
-      case BoUpdateLeader:
-        backOffFunction = BackOffFunction.create(1, 10, BackOffStrategy.NoJitter);
-        break;
-      case BoRegionMiss:
-        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.NoJitter);
-        break;
       case BoPDRPC:
-        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.EqualJitter);
+        backOffFunction = BackOffFunction.create(100, 600, BackOffStrategy.EqualJitter);
         break;
       case BoTiKVRPC:
-        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.EqualJitter);
+        backOffFunction = BackOffFunction.create(100, 400, BackOffStrategy.EqualJitter);
+        break;
+      case BoTxnNotFound:
+        backOffFunction = BackOffFunction.create(2, 500, BackOffStrategy.NoJitter);
         break;
     }
     return backOffFunction;