diff --git a/src/main/java/org/tikv/common/operation/iterator/ConcreteScanIterator.java b/src/main/java/org/tikv/common/operation/iterator/ConcreteScanIterator.java
index eb6a270f3e..72422736e7 100644
--- a/src/main/java/org/tikv/common/operation/iterator/ConcreteScanIterator.java
+++ b/src/main/java/org/tikv/common/operation/iterator/ConcreteScanIterator.java
@@ -77,6 +77,10 @@ public class ConcreteScanIterator extends ScanIterator {
       client.setTimeout(conf.getScanTimeout());
       BackOffer backOffer = ConcreteBackOffer.newScannerNextMaxBackOff();
       currentCache = client.scan(backOffer, startKey, version);
+      // If we get region before scan, we will use region from cache which
+      // may have wrong end key. This may miss some regions that split from old region.
+      // Client will get the newest region during scan. So we need to
+      // update region after scan.
       region = client.getRegion();
       return region;
     }
diff --git a/src/main/java/org/tikv/common/operation/iterator/RawScanIterator.java b/src/main/java/org/tikv/common/operation/iterator/RawScanIterator.java
index 5b27132699..08a64aaf87 100644
--- a/src/main/java/org/tikv/common/operation/iterator/RawScanIterator.java
+++ b/src/main/java/org/tikv/common/operation/iterator/RawScanIterator.java
@@ -57,6 +57,9 @@ public class RawScanIterator extends ScanIterator {
         } else {
           try {
             currentCache = client.rawScan(backOffer, startKey, limit, keyOnly);
+            // Client will get the newest region during scan. So we need to
+            // update region after scan.
+            region = client.getRegion();
           } catch (final TiKVException e) {
             backOffer.doBackOff(BackOffFunction.BackOffFuncType.BoRegionMiss, e);
             continue;
diff --git a/src/main/java/org/tikv/common/region/RegionStoreClient.java b/src/main/java/org/tikv/common/region/RegionStoreClient.java
index 42576fa7ea..5ba0dd104b 100644
--- a/src/main/java/org/tikv/common/region/RegionStoreClient.java
+++ b/src/main/java/org/tikv/common/region/RegionStoreClient.java
@@ -1253,6 +1253,9 @@ public class RegionStoreClient extends AbstractRegionStoreClient {
               regionManager, this, resp -> resp.hasRegionError() ? resp.getRegionError() : null);
       RawScanResponse resp =
           callWithRetry(backOffer, TikvGrpc.getRawScanMethod(), factory, handler);
+      // RegionErrorHandler may refresh region cache due to outdated region info,
+      // This region need to get newest ino from cache.
+      region = regionManager.getRegionByKey(key, backOffer);
       return rawScanHelper(resp);
     } finally {
       requestTimer.observeDuration();